Depression plus hostility poses heart risk Print E-mail

Older adults who are simultaneously hostile and depressed may be at increased risk for cardiovascular disease.

Depressive symptoms and hostility appear to act together in a complex way to influence levels of two inflammatory proteins that predict future heart disease, Dr. Jesse C. Stewart told Reuters Health.

Stewart, of Indiana University-Purdue University Indianapolis, and colleagues examined the relationships between depressive symptoms, hostility, and the blood levels of two inflammatory markers for cardiovascular disease -- interleukin-6 and C-reactive protein -- in 316 healthy men and women.

Depression and hostility levels of the participants, who ranged in age from 50 to 70 years old, were determined through responses to standard questionnaires, the investigators report in the medical journal Psychosomatic Medicine.

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