In a finding that is likely to revive a debate of many years about the safety of drugs prescribed for depression, health officials reported yesterday that the rate of suicide in Americans ages 10 to 24 increased 8 percent from 2003 to 2004, the largest jump in more than 15 years.

Some psychiatrists argue that the reason for the increase is the decline in prescriptions of antidepressant drugs like Prozac to young people since 2003, leaving more cases of serious depression untreated. Others say that it is impossible to know if the increase is linked to patterns of antidepressant prescriptions. The one-year spike in suicides could be a statistical fluctuation, they say, and not the start of a trend.

The increase was particularly sharp among adolescents, especially girls, according to the Centers for Disease Control and Prevention, which released the figures yesterday. The timing of the increase coincided with a public debate in the United States and overseas over whether the antidepressants increased the risk of suicide in a small percentage of young people who took them. In late 2004, after public hearings, the Food and Drug Administration called for drug makers to put a prominent “blackbox” warning on the drugs’ labels, cautioning about the possibility of increased suicide risk in minors.

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