| Genes Tied to Bad Reactions to Antidepressant Drug |
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Variations in two genes may increase the likelihood that a person will report suicidal thoughts after taking an antidepressant, researchers reported yesterday. The finding could help doctors develop tests to predict which patients will do well on such medications and which will react badly. The authors of the study, which was released to reporters yesterday and will appear in The American Journal of Psychiatry on Monday, said that the findings were preliminary and would need to be verified by further testing. The study focused on reactions to only one drug, Celexa from Forest Laboratories, and found no link between the gene variations and dangerous behavior like suicide attempts. This distinction is critical, because doctors do not know whether people who report thoughts of ending their lives are at increased risk to act on them. The one patient in the study who attempted suicide consistently denied having any suicidal thoughts.
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